Hello Mani
After doing some research I have found that this error appears whenever a device attempts multiple failed authentications within a specified period of time. This makes the “Client suppression mechanism” of the ISE kick in. This prevents DoS attacks. You can disable this feature in Administration > System > Settings > Radius, Suppress Anomalous Clients. You can also change the settings such as how long a client should be blocked.
More info about this can be found at this Cisco community thread:
Now this is the reason for the blocking. But why did your device have multiple failed attempts? The reason outlined in the output above shows 12511 Unexpectedly received TLS alert message. This seems to be the case when you use a wildcard certificate when the CN contains * as a wildcard. You can find out more about this at the following Cisco community thread:
Cisco also has official documentation about this here:
Hopefully this information will help you in your troubleshooting process…
I hope this has been helpful!
Laz